Activity of derivatives and analogs of dapsone against Mycobacterium leprae.
نویسنده
چکیده
Of 25 dapsone derivatives and analogs screened for activity against Mycobacterium leprae in the mouse footpad system, only 7 were active. All seven were metabolized to or contaminated with dapsone.
منابع مشابه
Synthesis and antileprosy activity of some dialkyldithiocarbamates.
OBJECTIVES To investigate the antileprosy potential of a set of original compounds with antimycobacterial activity. METHODS We developed a facile synthesis of 2-chloro-3-cyano-5-nitropyridine and synthesized a series of 3-cyano-2-dialkyldithiocarbamoyl-5-nitropyridine derivatives. In vivo therapeutic efficacy against Mycobacterium leprae was assessed in the infected mouse footpad model. RES...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 14 5 شماره
صفحات -
تاریخ انتشار 1978